Sengoku Youko: Yonaoshi Kyoudai-hen

The world is divided into two factions: humans and monsters called katawara. Despite being a katawara, Tama loves humans and vows to protect them from evil, even if it means fighting her own kind. Her brother Jinka, however, hates humans, despite mostly being one. The siblings are joined by a cowardly swordsman named Shinsuke, who wants to learn how to become strong. When the group uncovers a plot to experiment on humans and transform them into monsters, they vow to defeat whoever is behind it... Even if it means battling an entire army of warriors. (Source: Crunchyroll)